Plasma membrane cholesterol pools
نویسندگان
چکیده
منابع مشابه
Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it inhibits cholesterol synthesis by blocking activation of SREBPs. This feedback protects against cholesterol overaccumulation in the plasma membrane (PM). But how does ER know whether PM is saturated with cholesterol? In thi...
متن کاملDepletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts.
This study examines the relationship between cellular sphingomyelin content and the distribution of unesterified cholesterol between the plasma-membrane pool and the putative intracellular regulatory pool. The sphingomyelin content of cultured human skin fibroblasts was reduced by treatment of intact cells with extracellularly added neutral sphingomyelinase, and subsequent changes in the activi...
متن کاملRegulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol.
The abundance of cell cholesterol is governed by multiple regulatory proteins in the endoplasmic reticulum (ER) which, in turn, are under the control of the cholesterol in that organelle. But how does ER cholesterol reflect cell (mostly plasma membrane) cholesterol? We have systematically quantitated this relationship for the first time. We found that ER cholesterol in resting human fibroblasts...
متن کاملHeterogeneity of rabbit intestine brush border plasma membrane cholesterol.
Nonspecific lipid transfer protein accelerated cholesterol exchange from brush border vesicles according to a biphasic time course, but sonicated vesicles made from brush border phospholipids and glycosphingolipids showed a single phase exchange. Removal of surface protein with papain or opening brush border vesicles with deoxycholate did not abolish the biphasic exchange pattern. In brush bord...
متن کاملElevated plasma membrane cholesterol content alters macrophage signaling and function.
OBJECTIVE During atherogenesis, macrophages migrate into the subendothelial space where they ingest deposited lipoproteins, accumulate lipids, and transform into foam cells. It is unclear why these macrophages do not remove their lipid loads from the region. This study was aimed at testing the hypothesis that macrophage behavior is altered when membrane cholesterol levels are elevated, as might...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 1987
ISSN: 0968-0004
DOI: 10.1016/0968-0004(87)90173-3